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KMID : 0356720000160020087
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Journal of the Korean Society of Coloproctology
2000 Volume.16 No. 2 p.87 ~ p.92
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Prognostic Factors after Hepatic Resection for Metastatic Colorectal Cancer
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Kim Hee-Cheol
Kim Chang-Nam
Hong Hyun-Ki
Lee Dong-Hee
Yu Chang-Sik
Lee Je-Hwan
Kim Tae-Won
Kim Jin-Cheon
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Abstract
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Metastases to the liver from carcinoma of the colon and rectum occur as many as 80% of cases. As resection of metastases is proven to enhance survival and to reduce hepatic recurrence, the criteria for selection of patients and surgery type appear to be indispensable.
Purpose: The aim of this study was to assess the prognostic factors after hepatic resection for metastatic colorectal cancer and propose the optimal surgical principles for resection of metastatic colorectal cancer.
Methods: Sixty-three patients who underwent initial hepatic resection for liver metastases from colorectal cancer between 1989 and 1998 were analyzed regarding clinical and pathologic parameters.
Results: Overall 5-year survival rate was 32%. Preoperative serum CEA level and resection margin of metastatic tumors were found to be significant predictors for poor long-term outcome. Resection margin of greater than 5 mm was closely associated with better survival. In multivariate analysis, resection margin alone was an independent prognostic factor.
Conclusion: Preoperative serum CEA level and surgical resection margin may affect the outcome for the patients who underwent hepatic resection for metastatic colorectal cancer. Surgical resection margin must be kept enough to avoid re-recurrence or metastasis during hepatic resection for metastatic colorectal cancer.
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KEYWORD
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Colorectal cancer, Hepatic metastasis, Prognostic factors, Serum CEA, Resection margin
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